Translation of 'Finnegans Wake' sells in China

BEIJING (AP) ? The Chinese version is no easier to read than the original, the loyal-minded translator assures, but James Joyce's "Finnegans Wake" has still sold out its initial run in China.

Wang Weisong, chief editor of the Shanghai company that published the first Chinese translation of the Joyce classic, says he didn't expect success, but the first 8,000 copies have sold out since Dec. 25.

Dai Congrong, who spent eight years translating it, said at a forum in Shanghai that she didn't fully grasp the novel but that it wasn't intended for easy comprehension. She says she kept the Chinese version that way.

The book was promoted by a rare billboard campaign in Shanghai and other cities. Critics say it panders to a superficial demand among some Chinese for high-brow imports.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-01-29-AS-China-Finnegans-Wake/id-a3b4813bf3134dd78279e7fe3e27920f

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5.3-inch Spice Stellar Pinnacle Mi-530 hits India with a piquant 5MP front-facing camera

The large phone juggernaut rolls on with word on yet another contender raising its head in India, this time from the Spice stable. While the headline-grabbing 5-megapixel front camera may not be a world first, the Stellar Pinnacle Mi-530 rocks some decent specs for its Rs 13,999 ($260) asking price. The 5.3-inch qHD (960 x 540) IPS display hides a 1.2GHz dual-core chip, 1GB of RAM, 16GB storage, a microSD slot, dual-SIM support and an 8-megapixel rear snapper, all powered by a beefy 2,550mAh battery. We'd have preferred a more recent version of Mountain View's mobile OS instead of the Android 4.0 that the smartphone ships with, but it does attempt to spice up the offering with a bunch of software tricks, including Popup Play and Direct Call. Hardly ground-breaking, but hey, at least self-portrait addicts can indulge themselves without their hands tied.

Filed under: Cellphones, Mobile

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Source: http://www.engadget.com/2013/01/30/spice-stellar-pinnacle-mi530/

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'Master' proto-oncogene regulates stress-induced ovarian cancer metastasis

Jan. 29, 2013 ? Scientists at The University of Texas MD Anderson Cancer Center have discovered the signaling pathway whereby a master regulator of cancer cell proteins -- known as Src -- leads to ovarian cancer progression when exposed to stress hormones. The researchers report in the current issue of Nature Communications that beta blocker drugs mitigate this effect and reduce cancer deaths by an average of 17 percent.

Src (pronounced "sarc," short for sarcoma) is a proto-oncogene -- a normal gene that can become an oncogene due to increased expression -- involved in the regulation of cell growth and division. Known to be instrumental to changes that cause normal cells to go awry, this study sheds light on its functional role as a key molecular switch affecting a downstream signaling pathway that spurs disease progression.

Led by Anil K. Sood, M.D., professor in MD Anderson's Departments of Gynecologic Oncology and Cancer Biology, researchers found that noradrenaline (NA; a stress hormone) directly affects tumor growth and spread through beta-adrenergic (ADRB) receptors expressed on tumor cells. The study demonstrated that ADRB signaling leads to Src activation via a unique protein kinase A (PKA)-mediated mechanism, which is critical to the regulation of cellular activity and cancer metastasis. This is the first time that scientists have been able to show that ADRB receptors play a direct role in Src activation by this mechanism.

"When Src is triggered by stress, it works like a dam letting out water that causes a flood downstream. Src, like the dam, is a master regulator switch that causes a chain reaction in the cells," said Sood.

Based on existing findings of Sood's ongoing work exploring potential interventions against the effects of stress, the researchers examined data on outcomes of cancer patients treated with beta blocker drugs from the U.S. Food and Drug Administration Adverse Event Reporting System. They found that mortality in patients treated with a beta blocker was reduced by an average of 17 percent across all major cancer types. Moreover, they observed a nearly 15 percent decrease in mortality among patients with ovarian and cervical cancer.

Beta blockers, also called beta-adrenergic blocking agents, treat a variety of conditions, such as heart disease, high blood pressure, glaucoma and migraines. They act on the ADRB receptors, which are also found on the heart -- causing the heart to beat harder and faster under stress -- and are involved in maintaining blood flow.

When the ADRB receptors on cancer cells are activated, they set into motion a chain of events that leads to formation of new blood vessels that feed tumor growth -- a process known as angiogenesis. New blood vessel formation allows tumors to grow and spread more rapidly. Beta blocking agents stop this process.

"Prior to our work, the concept of stress hormones driving cancer growth was very new and only very limited information about the effect of beta blockers on cancer outcomes in humans has been available," said Guillermo Armaiz-Pena, Ph.D., instructor of Gynecologic Oncology and Reproductive Medicine and first author of the study. "This study provides incentive to further explore beta blockers as a possible supplement to traditional cancer therapies."

A Mystery Pathway Revealed

While NA -- the most abundant stress hormone in the ovary -- has been proven to modulate multiple cellular functions important for cancer progression, how it does so had remained a puzzle. Sood's team used a multi-step process to determine how the tumor microenvironment is disrupted by stress hormones.

First, the researchers exposed ovarian cancer cells to NA and identified a number of proteins altered by stress hormones. Using bioinformatics analysis, they narrowed potential mediators to Src.

A series of subsequent experiments designed to verify the biological roles of Src in promoting ovarian cancer tumor growth in response to stress hormones revealed the signaling pathway involved in NA-mediated Src activation. Specifically, they showed:

? PKA (also known as cAMP-dependent protein kinase) is the switch that "turns on" NA-induced Src activation; ? The signaling pathway occurs at a particular site on the cell known as S17; and ? This specific mechanism is key to mediating ADRB/cAMP/PKA-induced Src activation.

Building on the Stress-Cancer Connection For the past 13 years, Sood's research efforts have focused on the effects of chronic stress on cancer metastasis. The latest study helps form a more comprehensive picture on the impact of and biological mechanics of chronic stress on ovarian cancer, as well as the role of beta blockers in slowing disease progression. Previous studies have shown:

? Chronic stress triggers a chain of molecular events that protects breakaway ovarian cells from destruction, as heightened levels of the fight-or-flight hormones epinephrine and norepinephrine permit more malignant cells to safely leave the primary tumor -- a necessary step in metastasis and cancer progression.

? When mice with ovarian cancer are stressed, their tumors grow and spread more quickly, but the effect can be blocked using propranolol, a beta blocker commonly prescribed for heart disease.

Future research will focus on other biological mechanisms that may be affected by stress. Eventually, Sood hopes his studies will help identify the cancer patients most likely to benefit from beta blockers and other stress interventions. He is also looking at the impact of stress on other diseases, such as gastrointestinal disorders.

"This is a major step forward in understanding the biology and impact of stress on cancer progression and it opens the door to study drugs that could inhibit this unique signaling pathway," Sood said.

The current study was supported by grants from the NCI (F31CA126474), NIH (numbers CA101642, CA140933, CA104825, CA110793, CA109298, P50CA083639, P50CA098258, CA128797, RC2GM092599, U54CA96300, and U54CA96297), the Ovarian Cancer Research Fund, Zarrow Foundation, Department of Defense (numbers OC073399, W81XWH-10-1-0158, OC100237, and BC085265) Betty Ann Asche Murray Distinguished Professorship, the Marcus Foundation, RGK Foundation, Gilder Foundation, the estate of C.G. Johnson Jr., the Laura and John Arnold Foundation and the Blanton-Davis Ovarian Cancer Research Programme.

Co-authors of the paper from MD Anderson included Guillermo N. Armaiz-Pena Ph.D.; Julie K. Allen; Rebecca L. Stone, M.D.; Alpa M. Nick, M.D.; Yvonne G. Lin, M.D.; Liz Y. Han, M.D.; Lingegowda S. Mangala; Gabriel J. Villares; Pablo Vivas-Mejia, Ph.D.; Christian Rodriguez, Ph.D.; Archana S. Nagaraja; Kshipa M. Gharpure; Mian M.K. Shazhad, M.D.; Maya Zigler; Michael T. Deavers, M.D.; Gary E. Gallick, Ph.D; Menashe Bar-Eli, Ph.D.; and Gabriel Lopez-Berestein, M.D. Sood, Allen, Villares, Nagaraja, Gharpure and Zigler are also affiliated with The University of Texas Health Science Center. Other co-authors included Madeline Torres-Lugo, Ph.D., Gustavo E. Lopez, Ph.D. and Anthony Cruz, University of Puerto Rico; Zheng Wu, Ph.D., Robert D. English, Ph.D., Kizhake V. Soman, Ph.D. and John E. Wiktorowicz, Ph.D., University of Texas Medical Branch; Alexander Zien, Ph.D., Theodoros G. Soldatos and David B. Jackson, Molecular Health GmbH; Tom Young, Ph.D., Lehman College; Koen De Geest, M.D. and Susan K. Lutgendorf, Ph.D., University of Iowa; Steve W. Cole, Ph.D., University of California, Los Angeles.

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Story Source:

The above story is reprinted from materials provided by University of Texas M. D. Anderson Cancer Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Guillermo N. Armaiz-Pena, Julie K. Allen, Anthony Cruz, Rebecca L. Stone, Alpa M. Nick, Yvonne G. Lin, Liz Y. Han, Lingegowda S. Mangala, Gabriel J. Villares, Pablo Vivas-Mejia, Cristian Rodriguez-Aguayo, Archana S. Nagaraja, Kshipra M. Gharpure, Zheng Wu, Robert D. English, Kizhake V. Soman, Mian M. K. Shazhad, Maya Zigler, Michael T. Deavers, Alexander Zien, Theodoros G. Soldatos, David B. Jackson, John E. Wiktorowicz, Madeline Torres-Lugo, Tom Young, Koen De Geest, Gary E. Gallick, Menashe Bar-Eli, Gabriel Lopez-Berestein, Steve W. Cole, Gustavo E. Lopez, Susan K. Lutgendorf, Anil K. Sood. Src activation by ?-adrenoreceptors is a key switch for tumour metastasis. Nature Communications, 2013; 4: 1403 DOI: 10.1038/ncomms2413

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/yTx1bu1EI84/130129121843.htm

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Tips for Choosing a Title to Successfully Blog a Book

The title you choose when blogging a book plays a big role in your book?s success.

Writing a book as a series of blog posts is the most efficient way to get published. Blogging a book makes it easy to market and promote your book while you?re writing it.

More important, blogging a book provides breaks a big, easily put-off, task with a distant deadline into a series of short, attainable tasks with weekly deadlines.

The result? You?re you?re more likely to finish your book on time!

Choose book titles that create a structure

Look for a book title that provides a structure for writing your book as a series of short, self-contained chapters.

Today?s readers are in a hurry. They appreciate numerous short, focused, self-contained chapters containing practical advice that can be read in 5 or 10 minute increments before going to sleep, while commuting, or between appointments.

Looks for topics you can address in 2 to 6 page chapters; these make the best candidates for blogging a book.

Scott Parker?s (no relation) Web Designer?s 101 Most Important Decisions: Professional Secrets for a Winning Website provides an excellent example of a book topic you can write as a series of blog posts.

• Each page addresses a single topic. This focuses your reader?s attention on a single idea or principle, its relevance, and how to apply the information.
• Limited space leads to better writing. When writing to a one-page-per-chapter format, you tend to write better because you don?t have to ?fill up a lot of space.? As a result, it?s easier to get started. In addition, the limited space encourages you to edit your ideas to the bone, in order to make everything fit.
• Selective graphics. Books like The Web Designer?s 101 Most Important Decisions also tend to be visually interesting because the limited space available for graphics forces authors to be selective in the visuals they add to reinforce the text. The results, however, can be strikingly, as you?ll see from the book?s Amazon.com Look Inside! Feature.

Tips for successful book titles

Traditionally, the best nonfiction book titles have been described in terms of:

• Descriptive
• Benefit-oriented
• Specific
• Targeted
• Concise
• Positioned
• Alliterative

Now, at a time when books often first appear as a series of blog posts, it?s equally important that book titles create an obvious framework for writing the book, based on Ideas, Rules, Questions, Recommendations, Tips, and Things that other title ideas I?ve described in previous blog posts in this series.

Are you ready to blog a book?

Learn more about blogging a book, and other writing and content marketing topics, during Published & Profitable?s free January End-of-Month call, Tuesday, January 29, at 4 PM Eastern. To attend this free book coaching call simply call 605-475-6150 and enter PIN 513391#.

For more book and content marketing examples, ideas, and tips, plus a downloadable Title Evaluation Scorecard, check out, Write the Best Titles for Content Marketing: A Ten-Point Checklist. Share your questions and suggestions about book titles and blogging a book below, as comments.

Source: http://blog.publishedandprofitable.com/2013/01/28/tips-for-choosing-a-title-to-successfully-blog-a-book/

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OUYA gaming console gets 166 game prototypes thanks to 10-day ...

In case you?re concerned that the new OUYA gaming console is going to be vaporware, then worry no more because they recently held a 10-day ?game jam? called CREATE with the hope of seeing some game prototypes. I think it?s safe to say it was an astounding success as 166 game prototypes were created from every kind of genre including RPG?s, shooters, puzzlers, dungeon crawlers, fighting, and more.

These prototypes will be judged and the top developers will receive prizes, but you can also help out by sharing your favorites. Winning developers will obviously be that much closer to finishing their game. They also reported that the OUYA software package for making games has already been downloaded 22,000 times.

You can see the full list of games in the source link.

source: OUYA

?

? See more articles by Robert Nazarian

Source: http://www.talkandroid.com/149228-ouya-gaming-console-gets-166-game-prototypes-thanks-to-10-day-developers-jam/

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Lavrov: Iran and West need to set venue for talks

MOSCOW (AP) ? Russian Foreign Minister Sergey Lavrov said Monday that Iran and the West should stop behaving "like little children" and agree on where to hold talks on Tehran's nuclear program that were supposed to take place this month.

"We think the essence of our talks is far more important than the atmosphere of any given town," Lavrov said at a news conference. "We hope that common sense will prevail and we will stop being capricious like little children."

Iranian Foreign Minister Ali Akbar Salehi on Monday blamed the West for the holdup over the venue, striking back at the European Union, which last week accused Tehran of willfully delaying new nuclear talks with the six world powers by changing venues and using other stalling tactics.

Monday's statements by Salehi and Lavrov suggest no headway has been made on Iran's proposal of Egypt as the site to renew dialogue, more than six months since the last round ended in stalemate.

Salehi also suggested Turkey, which hosted one of the three rounds of talks Iran held last year with Britain, China, France, Germany, Russia and the United States.

The West has not given a definitive list of options, but Salehi said Kazakhstan, Switzerland and Sweden have been raised.

The talks had been planned for January, but with less than a week remaining in the month they will most likely have to be delayed.

The last round of nuclear talks ended in stalemate in Moscow in June, triggering new international sanctions that have been pressing hard on the Iranian economy.

The West demands that Iran halt its highest-level enrichment of uranium, which Washington and others fear could quickly be turned into nuclear warhead-grade material.

Iran insists it does not seek nuclear arms ? repeatedly citing a 2005 edict by Supreme Leader Ayatollah Ali Khamenei that called atomic weapons a violation of Islamic tenets ? and says it only wants to enrich uranium to make fuel for reactors.

Iran's leaders know the only route to ease the economic pressures ? and possibly undercut threats of military action on its nuclear sites by Israel ? is through potential deal-making with the six world powers.

Source: http://news.yahoo.com/lavrov-iran-west-set-venue-talks-110411593.html

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Time to Getaway Staycation with the Ritz-Carlton, Millenia Singapore

Weekend stay-cations are now tailored to guests? needs and schedules at The Ritz-Carlton, Millenia Singapore with check-in times that guests can personally choose.

With Time to Getaway, guests enjoy $20 off their package rate every hour after 2pm that they opt to check-in, up to a maximum limit of $80 off i.e.

• Check-in from 3pm: $20 off
• Check-in from 4pm: $40 off
• Check-in from 5pm: $60 off
• Check-in from?6pm: $80 off

Time to Getaway is available from Fridays to Mondays from 1 to 31 January and 1 to 31 March. In addition, guests will enjoy an in-room breakfast for two and $50 hotel credit which can be used for dining, at the retail shop and spa.

Prices are quoted in Singapore dollars and are subject to 10 percent service charge and prevailing government taxes. Reservations are subject to availability and can be made by calling (65) 6434 5118 or emailing [email?protected]

Well-positioned along Singapore?s Marina Bay, this newly-renovated 608-room luxury hotel continues to be the city?s foremost hotel with award-winning hospitality synonymous with the Ritz-Carlton brand and breathtaking views. The hotel is located minutes away from attractions such as the ArtScience Museum, Integrated Resorts, Esplanade-Theatres on the Bay and the Singapore Flyer whilst two shopping malls are accessible via covered skybridge with over 2,000 shopping and dining options.

With restaurants and food and beverage options voted by readers of Travel and Leisure as ?The Best in Singapore?, The Ritz-Carlton, Millenia Singapore is set amidst seven acres of tropical landscape. All guest rooms and bathrooms offer views of either Marina Bay or the city skyline.? Services and facilities include restaurants and a lounge serving Chinese, Western and international favourites; a Fitness Centre with swimming pool, indoor gym and treatment rooms; and a business centre.

Source: http://www.passportchop.com/advertorial/time-to-getaway-staycation-ritz-carlton/

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Egypt's leader declares emergency after clashes

CAIRO (Reuters) - Egyptian President Mohamed Mursi declared a month-long state of emergency in three cities along the Suez Canal where dozens of people have been killed over the past four days in protests his allies say are designed to overthrow him.

Seven people were shot dead and hundreds were injured in Port Said on Sunday during the funerals of 33 people killed there when locals angered by a court decision went on the rampage as anti-government protests spread around the country.

A total of 49 people have been killed since Thursday and Mursi's opponents, who accuse his Islamist Muslim Brotherhood of betraying the revolution that ousted long-time ruler Hosni Mubarak, have called for more demonstrations on Monday.

"Down, down Mursi, down down the regime that killed and tortured us!" people in Port Said chanted as the coffins of those killed on Saturday were carried through the streets.

Mursi, who was elected in June, is trying to fix a beleaguered economy and cool tempers before a parliamentary poll in the next few months which is supposed to cement Egypt's transition to democracy. Repeated eruptions of violence have weighed heavily on the Egyptian pound.

In a televised address, he said a nightly curfew would be introduced in Port Said, Ismailia and Suez, starting Monday.

Several hundred people protested in Ismailia, Suez and Port Said after the announcement, in which Mursi also called for a dialogue with top politicians. Activists in the three cities vowed to defy the curfew in protest at the decision.

"The protection of the nation is the responsibility of everyone. We will confront any threat to its security with force and firmness within the remit of the law," he said, offering condolences to families of the victims.

In Cairo the newly appointed Interior Minister Mohamed Ibrahim was ejected from the funeral of one of the police officers who died during Saturday's clashes in Port Said, according to witnesses and police sources.

A police officer at the funeral said many of his colleagues blame the interior minister for the deaths of at least two policemen during Saturday's clashes as he did not allow the police there to carry weapons and were only given teargas bombs.

SECURITY MEASURES

The violence has exposed a deep rift in the nation. Liberals and other opponents accuse Mursi of failing to deliver on economic promises and say he has not lived up to pledges to represent all Egyptians. His backers say the opposition is seeking to topple Egypt's first freely elected leader.

Distancing itself from the latest flare-ups, the opposition National Salvation Front said Mursi should have acted far sooner to impose extra security measures that would end the violence.

"Of course we feel the president is missing the real problem on the ground which is his own polices," spokesman Khaled Dawoud told Reuters. "His call to implement emergency law was an expected move given what is going on, namely thuggery and criminal actions."

The Front, formed late last year when Mursi provoked protests and violence by expanding his powers and driving through an Islamist-tinged constitution, has threatened to boycott the parliamentary poll and call for more protests if its demands are not met, including for an early presidential vote.

State television said seven people died from gunshot wounds in Port Said on Sunday. Port Said's head of hospitals, Abdel Rahman Farag, told Reuters more than 400 people had suffered from teargas inhalation, while 38 were wounded by gunshots.

Gunshots had killed many of the 33 who died on Saturday when residents rioted after a court sentenced 21 people, mostly from the Mediterranean port, to death for their role in deadly soccer violence at a stadium there last year.

A military source said many people in Port Said, which lies next to the increasingly lawless Sinai Peninsula, possess guns because they do not trust the authorities to protect them. However it was not clear who was behind the deaths and injuries.

In Cairo, police fired teargas at dozens at protesters throwing stones and petrol bombs in a fourth day of clashes over what demonstrators there and in other cities say is a power grab by Islamists two years after Mubarak was overthrown.

In Ismailia city, which lies on the Suez Canal between the cities of Suez and Port Said, police also fired teargas at protesters attacking a police station with petrol bombs and stones, according to witnesses and a security source there.

"KNEE-JERK REACTION"

Most of the deaths since Thursday were in Port Said and Suez, both cities where the army has now been deployed.

Heba Morayef of Human Rights Watch in Cairo said a state of emergency reintroduced laws that gave police sweeping powers of arrest "purely because (people) look suspicious".

"It is a classic knee-jerk reaction to think the emergency law will help bring security," she said. "It gives so much discretion to the Ministry of Interior that it ends up causing more abuse which in turn causes more anger."

The opposition Popular Current and other groups have called for more protests on Monday to mark what was one of the bloodiest days of the 2011 uprising.

Anti-Mursi protesters who have been camped out in Tahrir Square for weeks also demonstrated against Mursi's move to impose a state of emergency, reviving memories of Mubarak's era when emergency codes were in place for three decades and used to crush dissent and detain people without charge.

Protesters say Mursi has betrayed the revolution's aims.

"None of the revolution's goals have been realized," said Mohamed Sami, a protester in Cairo's Tahrir Square, the cauldron of the uprising that erupted on January 25, 2011 and toppled Mubarak 18 days later.

"Prices are going up. The blood of Egyptians is being spilt in the streets because of neglect and corruption and because the Muslim Brotherhood is ruling Egypt for their own interests."

Clashes also erupted in other streets near the square. The U.S. and British embassies, both close to Tahrir, said they were closed for public business on Sunday, normally a working day.

The army, Egypt's interim ruler until Mursi's election, was sent back onto the streets to restore order in Port Said and Suez, which both lie on the Suez canal. In Suez, at least eight people were killed in clashes with police.

Many ordinary Egyptians are frustrated by the violence that have hurt the economy and their livelihoods.

"They are not revolutionaries protesting," said taxi driver Kamal Hassan, 30, referring to those gathered in Tahrir. "They are thugs destroying the country."

(Additional reporting by Shaimaa Fayed in Cairo and Yusri Mohamed in Ismailia; editing by Philippa Fletcher)

Source: http://news.yahoo.com/riots-over-egyptian-death-sentences-kill-least-32-005245042.html

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Heat Shock Proteins May Shed New Light on a Variety of Debilitating Diseases

Jan. 28, 2013 ? UCLA researchers, in a finding that runs counter to conventional wisdom, have discovered for the first time that a gene thought to express a protein in all cells that come under stress is instead expressed only in specific cell types.

The group, from the Jules Stein Eye Institute and UCLA Pulmonary and Critical Care Medicine, focused on ?B-Crystallin, a small heat shock protein. Heat shock proteins are a class of functionally-related proteins involved in the folding and unfolding of other proteins. Their expression is increased when cells are exposed to taxing environmental conditions, such as infection, inflammation, exercise, exposure to toxins and other stressors.

?B-Crystallin may be associated with certain cancers and could be developed into a biomarker to monitor for diseases such as multiple sclerosis, age-related macular degeneration, heart muscle degeneration and clouding of the eye lens. Any discoveries about how this protein is regulated and its molecular biology may reveal potential targets for novel therapies, said study first author Zhe Jing, a research associate in UCLA Pulmonary and Critical Care Medicine.

"If you use a certain cell type, this protein can be induced when the cells are stressed, but that doesn't happen in a different cell type," said Jing. "This novel finding does conflict with what has been thought, that this protein could be induced in any cell type."

The findings of this two-year study are published in the most recent issue of the journal Cell Stress and Chaperones, a peer-reviewed journal in the fields of cell stress response.

The UCLA team did the study using four cell lines -- two epithelial cells lines and two fibroblast cells lines. They found that the protein cannot be induced by stress in epithelial cells, in which 80 percent of cancers arise. It can, however, be induced in the fibroblasts that make up muscle tissue.

The significant finding in this investigation is that, in certain cell types, only one specific heat shock factor controls the expression of ?B-Crystallin. For example, in the epithelial cell lines, it is heat shock factor 4 (HSF4), while a different heat shock factor, (HSF1), plays this role in the fibroblast cells lines.

In the past, the data has indicated that a heat shock factor could control the expression of ?B-Crystallin randomly and equally. However, Jing's discovery overrides this rule. His findings strongly suggest the "preference" of the ?B-Crystallin to heat shock factors in certain cells may be correlated with its versatility to various diseases.

"Considering the multiple roles of ?B-Crystallin in so many diseases, the access of the HSF1 and HSF4 to the ?B-Crystallin gene dictated by the certain cell type may be what is helping to cause certain diseases," Jing said. "If we can uncover the cascade of events that result in disease, we may be able to come up with strategies to block or interrupt that cascade."

Going forward, Jing and the research team will validate what they found in this study by examining single cells, which provides a greater challenge but may lead to further discoveries.

The study was funded by the National Institutes of Health.

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Story Source:

The above story is reprinted from materials provided by University of California, Los Angeles (UCLA), Health Sciences, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Zhe Jing, Rajendra K. Gangalum, Josh Z. Lee, Dennis Mock, Suraj P. Bhat. Cell-type-dependent access of HSF1 and HSF4 to ?B-crystallin promoter during heat shock. Cell Stress and Chaperones, 2012; DOI: 10.1007/s12192-012-0386-7

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/hjNlftasC14/130128163338.htm

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Stretching for Pain Relief | Natural Holistic Health Blog

Stretching your body?s muscles will actually enhance the healing process.

Next to breathing and breath work, stretching is the most beneficial exercises we can do for better health.

Done in tandem, breath work and stretching are the best support for easing aches, pain, tension, headaches, tight muscles and unexplained pain elsewhere in the body.

The different types of stretching

Just as there are different types of flexibility, there are also different types of stretching. Stretches are either dynamic (meaning they involve motion) or static (meaning they involve no motion).

Dynamic stretches affect dynamic flexibility and static stretches affect static flexibility (and dynamic flexibility to some degree).

When done properly, stretching can do more than just increase flexibility.

Benefits of stretching include:

• ?enhanced physical fitness
• ?enhanced ability to learn and perform skilled movements
• ?increased mental and physical relaxation
• ?enhanced development of body awareness
• ?reduced risk of injury to joints, muscles, and tendons
• ?reduced muscular soreness
• ?reduced muscular tension
• ?increased suppleness due to stimulation of the production of chemicals which, lubricate connective tissues
• ?reduced severity of painful menstruation (dysmenorrhea) in females

Things to remember when beginning a stretching routine:

• Wear comfortable clothes that won?t restrict body movement
• Stretching should be pain free; don?t force the body into difficult positions
• Move into each stretch slowly and avoid bouncing, which can actually tear muscles
• Stretch on a clean, flat surface which is large enough to move freely
• Hold stretches long enough (20-30 seconds) to allow muscles or joints to become loose
• Repeat the stretch, generally 5 ? 10 times

The most effective stretches

One good over all stretch for your body is to lie on the floor and gently bring your knees up to your chest. Once there, put a little pressure on your knees with two hands.

Gently raise your head up toward the knees. Breath, in, out, in out?..slowly. Stretch, then relax. Repeat.

The effect of stretching on healing

Stretching your body?s muscles will actually enhance the healing process.

Long, slow static stretching will help to increase blood flow and circulation, eliminating stasis and help to warm and invigorate the muscles and in turn lubricate the ligaments and joints.

Stretching the whole body will help heal pain even if that pain is localized to one area. This is true because all areas of the body are connected through the fascia which is a sheath that covers and surrounds all of the musculature throughout the body. So, it?s important to stretch the whole body.

One of the best over all stretches is the Sun Salutation

Click image for larger picture and instructions

Nutritional supplements can help joint health and inflammation

Arthritis is not a ?natural part of aging?. Over 100 forms are preventable and potentially curable. Providing the body with the correct nutrients to help this process is a significant step in the right direction in achieving this objective. Arthrit-Eze is probably the most advanced natural formula on the market today.

It offers potential relief and rejuvenation for all forms of arthritis, safely, naturally and without side effects. Our R & D team has researched each ingredient in the formula?at molecular level to ensure synergy and maximum efficacy. These ingredients have been combined into a single product tablet.

It is arguably the most effective natural formula of its type in the world. Unlike many prescription products for arthritis, Arthrit-Eze has no negative side effects. ?PLUS, customers report added benefits of better skin, and overall well-being!

Natural remedies for pain management can also be effective

InflammaGo is a safe, non-addictive, FDA-registered natural remedy containing 100% homeopathic ingredients selected to relieve pain and stiffness in joints and muscles associated with arthritis. InflammaGo can safely maintain joint health and support healthy tissues in the body, without harmful side effects.

This remedy contains a selection of homeopathic ingredients known to address muscle and joint inflammation and fatigue. It also helps provide relief for sports injuries, plus healing after over-exertion and physical stress. Learn more about InflammaGo now.

Free PDF Health Ebook...

Natural Beauty, Natural Glow

? ? Simply right click the ebook title above, and choose Save As to save to your desktop!? You can find more FREE Natural Health, Wellness and Pet Ebooks at Remedies4.com!

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About Andrew Pacholyk

Andrew Pacholyk, MS, L.Ac. has been in the alternative health field for over 15 years. His knowledge, expertise and clinical training has offered him the ability to experience and continually learn about the body and its energy system in health as well as in disease. Visit Andrew's site, Peaceful Mind for more information!

Source: http://www.natural-holistic-health.com/stretching-for-pain-relief/?utm_source=rss&utm_medium=rss&utm_campaign=stretching-for-pain-relief

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'Argo' Wins PGA Award: Ben Affleck Drama Named Best 2012 Film By Producers Guild

"Argo" took a big step toward becoming only the fourth film in the history of the Academy Awards to win Best Picture without a Best Director nomination as it captured the Producers Guild Award on Saturday night.

Ben Affleck, George Clooney and Grant Heslov won the Darryl F. Zanuck Award for Outstanding Producer of Theatrical Motion Pictures at the Producers Guild Awards, beating the producers of "Lincoln," "Silver Linings Playbook," "Zero Dark Thirty," "Les Miserables," "Life of Pi," "Django Unchained," "Skyfall," "Moonrise Kingdom" and "Beasts of the Southern Wild."

"I'm really surprised. I'm not even in the PGA," Affleck joked while accepting the award. "I am still acting."

For Oscar experts, the PGA award is a significant Academy Awards precursor: Only seven times in 24 years has the Darryl F. Zanuck winner failed to capture Best Picture at the Oscars. The last five films to take home the PGA award also won on Oscar night.

"Lincoln" was a presumed favorite for the PGA award, alongside "Silver Linings Playbook." Both films, as well as "Argo," are up for Best Ensemble at the Screen Actors Guild Awards, which is the SAG equivalent of Best Picture. The SAG awards, another strong precursor, will be handed out on Sunday evening.

For more winners from the PGA awards, head over to THR.

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Source: http://www.huffingtonpost.com/2013/01/27/argo-wins-pga-award_n_2560490.html

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U.S. to support French in Mali with aerial refueling

WASHINGTON (AP) ? The United States has decided to provide additional support to the French military in its war against Islamic militants in Mali by conducting aerial refueling missions.

The Pentagon says Defense Secretary Leon Panetta has told the French defense minister, Jean-Yves Le Drian, that U.S. Africa Command will provide the aerial refueling support. A Pentagon spokesman says the two defense officials discussed the refueling missions and other topics during a phone conversation Saturday.

U.S. aerial refueling planes would be a boost to air support for French ground forces as they enter areas of Mali that are controlled by al-Qaida-linked extremists.

The U.S. has already been helping France by transporting French troops and equipment to the West African nation.

Source: http://news.yahoo.com/us-support-french-mali-aerial-refueling-021029750.html

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Property Taxes and the Achievement Gap - MN2020 Hindsight

By Bryan Martin, Undergraduate Research Fellow, January 25, 2013 at 7:30 am

Over the past 10 years, Minnesota has followed the increasing nationwide trend in using property taxes to finance schools. In 2003, state aid provided 75% of school revenue, now state aid provides 66% of school revenue. Steep cuts and local property taxes make up a majority of the lost revenue, increasing from 12% of total school revenue to 20%.

This trend puts enormous pressure on property poor districts to keep up with wealthier areas of the state, which tend to be rural communities and many of the first-ring suburbs. Levying a percentage on the value of a $350,000 home yields a much larger return than $125,000 property, making it hard for property poor districts to overcome state cuts.

?

Source: Minnesota Department of Education

Several studies confirm that family income also correlates with student achievement, so these wealthier districts are already at an advantage.? Minnesota's achievement gap puts us in the bottom half of states, and increasing a funding gap isn?t going to help. Money does matter in education.

Minnesota must recommit to a more equitable education and community investment policy, which go hand-in-hand when it comes to closing an achievement gap. We had been served well by a system where the state used its vast taxing authority?sales, income, property?to raise revenue in a progressive manner, then equitably invested in community assets statewide. Minnesota should move forward together?no one community would be left too far behind, and no one community should advance too much farther ahead, according to the theory.

Instead, a decade of "no-new-tax" state policy has hampered our ability to make good on that promise to collect revenue progressively and make statewide investments. It's produced budget deficit after budget deficit. In turn, lawmakers balanced about a decade of state budget gaps by shorting schools and cutting revenue sharing with local communities.??

The burden fell to property taxpayers and you're familiar with the results. Governor Dayton's fiscal overhaul takes a step forward toward recommitting Minnesota to the promise of shared prosperity.

His proposals direct more state money to schools, which includes free all-day kindergarten funding for districts choosing to offer it. All-day kindergarten has documented and reported benefits for children, and could go far in helping get students susceptible to the achievement gap ready for 1st grade. (Watch our Early Start for Future Success video on what students learn in kindergarten.)?

Furthermore, he's easing overall pressure on local property taxpayers in two ways: increasing state revenue sharing with local governments and offering $500 property tax rebates.

Property taxes will still be part of the funding mix, and for the short-term a big part of the school funding mix. But in the future, the goal is to shift education opportunity away from a community's willingness or ability to pass a school levy or property wealth and back to fair and equatable funding for a world class education regardless of zip code.?

Posted in Education | Related Topics: "No New Taxes"? Education Funding? Property Tax?

Source: http://www.mn2020hindsight.org/view/property-taxes-and-the-achievement-gap

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Thawing 'dry ice' drives groovy action on Mars

Jan. 25, 2013 ? Researchers using NASA's Mars Reconnaissance Orbiter see seasonal changes on far-northern Martian sand dunes caused by warming of a winter blanket of frozen carbon dioxide.

Earth has no naturally frozen carbon dioxide, though pieces of manufactured carbon-dioxide ice, called "dry ice," sublime directly from solid to gas on Earth, just as the vast blankets of dry ice do on Mars. A driving factor in the springtime changes where seasonal coverings of dry ice form on Mars is that thawing occurs at the underside of the ice sheet, where it is in contact with dark ground being warmed by early-spring sunshine through translucent ice. The trapped gas builds up pressure and breaks out in various ways.

Transient grooves form on dunes when gas trapped under the ice blanket finds an escape point and whooshes out, carrying out sand with it. The expelled sand forms dark fans or streaks on top of the ice layer at first, but this evidence disappears with the seasonal ice, and summer winds erase most of the grooves in the dunes before the next winter. The grooves are smaller features than the gullies that earlier research linked to carbon-dioxide sublimation on steeper dune slopes.

Similar activity has been documented and explained previously where seasonal sheets of frozen carbon dioxide form and thaw near Mars' south pole. Details of the different northern seasonal changes are newly reported in a set of three papers for the journal Icarus. A video showing some of the changes is online at http://www.jpl.nasa.gov/video/index.php?id=1184 .

The findings reinforce growing appreciation that Mars today, however different from its former self, is still a dynamic world, and however similar to Earth in some respects, displays some quite unearthly processes.

"It's an amazingly dynamic process," said Candice Hansen of the Planetary Science Institute, Tucson. She is lead author of the first of the three new reports. "We had this old paradigm that all the action on Mars was billions of years ago. Thanks to the ability to monitor changes with the Mars Reconnaissance Orbiter, one of the new paradigms is that Mars has many active processes today."

With three Martian years (six Earth years) of data in hand from the Mars Reconnaissance Orbiter's High Resolution Imaging Science Experiment (HiRISE) camera, the researchers report on the sequence and variety of seasonal changes. The spring changes include outbursts of gas carrying sand, polygonal cracking of the winter ice blanketing the dunes, sandfalls down the faces of the dunes, and dark fans of sand propelled out onto the ice.

"It is a challenge to catch when and how those changes happen, they are so fast," said Ganna Portyankina of the University of Bern in Switzerland, lead author of the second report. "That's why only now we start to see the bigger picture that both hemispheres actually tell us similar stories."

The process of outrushing gas that carves grooves into the northern dunes resembles the process creating spider-shaped features in far southern Mars, as seen in an image at http://photojournal.jpl.nasa.gov/catalog/PIA12249, but the spiders have not been seen in the north. The seasonal dry-ice sheets overlie different types of terrain in the two hemispheres. In the south, diverse terrains include the flat, erodible ground where the spiders form, but in the north, a broad band of sand dunes encircles the permanent north polar ice cap.

Another difference is in brightening on parts of the ice-covered dunes. This brightening in the north results from the presence of water-ice frost, while in the south, similar brightening is caused by fresh carbon dioxide. The third paper of the Icarus set, by Antoine Pommerol of the University of Bern and co-authors, reports distribution of the water frost using the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM). The light water frost is blown around by spring winds.

The University of Arizona, Tucson, operates the HiRISE camera, which was built by Ball Aerospace & Technologies Corp., Boulder, Colo. The Johns Hopkins University Applied Physics Laboratory, Laurel, Md., provided and operates CRISM. NASA's Jet Propulsion Laboratory, a division of the California Institute of Technology in Pasadena, manages the Mars Reconnaissance Orbiter for NASA's Science Mission Directorate in Washington. Lockheed Martin Space Systems, Denver, built the orbiter. For more about the mission, visit: http://www.nasa.gov/mro .

A slide show of Martian icy scenes is online at: http://1.usa.gov/ZoAO8I .

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The above story is reprinted from materials provided by NASA/Jet Propulsion Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/Bl0tO9lJq3g/130125095328.htm

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Notre Dame's Te'o says had no part in forming hoax

Jan 24 (Reuters) - Notre Dame football player Manti Te'o said he was the victim of an elaborate online hoax and denied in an interview broadcast on Thursday having had any part in the construction of the dramatic story of his dying girlfriend.

"No, I did not," Te'o said in the interview with Katie Couric broadcast on the daytime talk show "Katie." "I think what people don't realize is that the same day that everybody else found out about this situation, I found out."

The reported deaths of Te'o's grandmother and purported girlfriend, both on Sept. 12, and his response to the tragedies, were often repeated stories during Notre Dame's bid for a national championship last season. His grandmother did die that day.

Te'o, who was a finalist for college football's highest individual honor for helping drive Notre Dame to an undefeated regular season, admitted he maintained the public deception after he learned the truth that she had never existed, but he did not do so for personal gain.

Couric asked Te'o to respond to several theories people have raised since the hoax was revealed, including that he might be gay and created the relationship to hide his sexual orientation.

"No, far from it," Te'o said when asked by Couric if he were gay. "Far from that."

Te'o sat with his hands often clasped and responded in a soft tone to Couric's questions, telling her he did not know if the Lennay Kekua story had supported his Heisman trophy candidacy.

It was his first on-camera interview since sports blog Deadspin.com broke the story on Jan. 16 that Kekua did not exist. Couric also interviewed his parents, Brian and Ottilia Te'o, who defended their son.

Notre Dame, one of the most powerful institutions in U.S. collegiate athletics, held a news conference within hours of the Deadspin.com story to say that Te'o had been duped.

Te'o had told sports network ESPN in an off-camera interview on Friday that an acquaintance, Ronaiah Tuiasosopo, had told him he was behind the hoax.

CONFESSED HOAX

Te'o said in the interview with Couric that Tuiasosopo, who he had spoken to twice before and had believed was Kekua's cousin, confessed the hoax to him on Jan. 16.

Te'o said he received a telephone call from the person claiming to be Kekua on Dec. 6 - two days before the Heisman presentation - and he wasn't really certain she never existed until Tuiasosopo's confession to him.

"My whole reality was she was dead, and now all of the sudden she's alive. At that time I didn't know that it was just somebody's prank."

He went along with the Kekua story the day of the Heisman presentation, though he knew at a minimum that she was alive, and did not tell his parents until Christmas, he said.

"Part of me was saying that if you say she is alive what would everybody think? What are you going to tell everybody who follows you, who you inspire? What are you going to say? At that time, on Dec. 8, two days after I just found out she was alive, as a 21-year-old, I wasn't ready for that."

Te'o said he "wasn't forthcoming" about the extent of his relationship with Kekua, that they had never met in person, but reporters did not ask him directly if they had met in person.

He said he was most sorry for having told his father he had seen Kekua in person when he was in Hawaii, a story that his father repeated to media when asked.

When asked why he wouldn't simply want a girlfriend he could spend time with on campus, Te'o said he was drawn to Kekua because her background appeared similar to his own.

"What I went through was real," Te'o said. "The feelings, the pain, the sorrow, that was all real. That is something I can't fake."

Te'o said he did not know how the hoax would affect his position in the National Football League draft.

"As far as my draft status, I hope and pray that good happens obviously, but as long as my family is OK, I can live with whatever happens," he said. (Reporting by David Bailey; Editing by Cynthia Johnston and Tim Dobbyn)

Source: http://news.yahoo.com/notre-dames-teo-says-had-no-part-forming-001009213--nfl.html

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Twitter ordered to ID anti-Semitic tweeters

14 hrs.

Brian Love , Reuters

PARIS ???A French court on Thursday ordered Twitter to help identify the authors of anti-Semitic posts or face fines of the?equivalent?of?$1,300?a?day, as the social network firm comes under renewed pressure to combat racist and extremist messages.?

The order, requested by a Jewish student union and rights groups, concerned anti-Semitic material but could open the floodgates to legal pursuit of Twitter users who post a wide range of messages deemed illegal or offensive.?

"This is an excellent decision, which we hope will bring an end to the feeling of impunity that fuels the worst excesses," said Stephane Lilti, lawyer for the groups who sought the ruling.?

The anti-Semitic messages started appearing last October, and have since been deleted.?

The Paris court gave privately?held Twitter, whose general policy is that it does not control content posted on its network, 15 days to hand over data identifying people who have published messages judged anti-Semitic.?

The court also ordered Twitter to set up a system in France that helps people draw attention to illegal content. Under French law, people found guilty of inciting racial hatred can be jailed for a year and fined.?

Twitter's lawyer in France, Alexandra Neri, declined to comment.?

Failure to comply would expose the firm, founded in 2006 and now boasting 140 million monthly active users worldwide, to daily fines of 1,000 euros if the groups who sought the order request it, which Lilti said they would not hesitate to do.?

A rights group involved in the case was quick to point out that the injunction, while limited to a case of anti-Semitic traffic, set a precedent that could also have a wider impact.?

"This marks a decisive step forward in the battle against racist, homophobic and anti-Semitic offences on the Internet," the International League Against Racism and Anti-Semitism (LICRA) said in a statement.?

"Nobody can ignore French law, not even the giants of the American digital economy."?

For a first time, Twitter deployed a new message-blocker in Germany last October to jam the posting of messages by a neo-Nazi group banned by police.?

A tool Twitter calls "country withheld content" allows it to censor tweets considered illegal in a given country.?

Copyright 2013 Thomson Reuters.

Source: http://www.nbcnews.com/technology/technolog/twitter-ordered-id-anti-semitic-tweeters-france-1C8103590

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NASA's Opportunity Rover Begins Year 10 on Mars

The older, smaller cousin of NASA's huge Mars rover Curiosity is quietly celebrating a big milestone today (Jan. 24) ? nine years on the surface of the Red Planet.

NASA's Opportunity rover landed on Mars the night of Jan. 24, 2004 PST (just after midnight EST on Jan. 25), three weeks after its twin, Spirit, touched down. Spirit stopped operating in 2010, but Opportunity is still going strong, helping scientists better understand the Red Planet's wetter, warmer past.

"No one could've imagined how good the exploration and scientific discovery would be for this vehicle, looking from the perspective of nine years ago," said John Callas, Opportunity's project manager at NASA's Jet Propulsion Laboratory in Pasadena, Calif. "It's been a phenomenal accomplishment."

The headline-stealing Curiosity rover, for its part, touched down on Aug. 5, 2012, marking the next step in Mars exploration. The car-size Curiosity weighs about 1 ton ? five times more than either Spirit or Opportunity.

Long-lived rovers

Spirit and Opportunity were originally supposed to spend three months searching for evidence of past water activity on the Red Planet. The golf-cart-size robots found plenty of such signs at their separate landing sites, showing that Mars was not always the cold and arid planet we know today. [Most Amazing Discoveries by Spirit and Opportunity]

For example, in 2007 Spirit uncovered an ancient hydrothermal system in Gusev Crater, suggesting that two key ingredients for life as we know it ? liquid water and an energy source ? were both present in some parts of Mars long ago.

And Opportunity is currently inspecting clay deposits along the rim of Mars' huge Endeavour Crater. Clays form in relatively neutral (as opposed to acidic or basic) water, so the area may once have been capable of supporting primitive microbial life, researchers say.

"This is our first glimpse ever at conditions on ancient Mars?that clearly show us a chemistry that would've been suitable for life at the Opportunity site," Opportunity principal investigator Steve Squyres, of Cornell University, said of the discovery at a conference last month.

The rovers rolled far beyond their 90-day warranties. Spirit finally stopped communicating with Earth in March 2010, after getting mired in soft sand and failing to maneuver into a position that would allow it to slant its solar panels toward the sun over the 2009-2010 Martian winter. NASA declared the rover dead in 2011.

But Opportunity keeps chugging along. It has put 22.03 miles (35.46 kilometers) on its odometer since landing on Mars ? just 1 mile (1.6 km) off the all-time record for most ground covered on the surface of another world. The Soviet Union's unmanned Lunokhod 2 rover holds that mark, traveling 23 miles (37 km) on the moon back in 1973.

The great engineering that allowed Spirit and Opportunity to keep roving for so long is a big part of the six-wheeled robots' legacy, mission team members say.

"These are magnificently designed machines," Callas told SPACE.com. "We really have greatly expanded the exploration envelope by having a vehicle that can not only last so long but stay in very good health over that time, such that we can continue exploring."

Still in good health

While Opportunity is showing signs of its advanced age, such as an arthritic robotic arm, the rover remains in good shape overall.

"Its health right now is miraculously good," Callas said.

Still, the rover team is treating every day as a gift at this point, knowing that Opportunity could conk out at pretty much any time. Indeed, the sun will rise one day without a message from Opportunity, and its handlers will have to face the rover's death and the end of an amazing mission.

"It's going to be hard; it'll be the end of a great era," Callas said. "But we'll have to remember that we've had such a good run."

Follow SPACE.com senior writer Mike Wall on Twitter @michaeldwall?or SPACE.com @Spacedotcom. We're also on Facebook?and?Google+.?

Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/nasas-opportunity-rover-begins-10-mars-125036382.html

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Video: Bright Horizons Surges in Debut

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Source: http://video.msnbc.msn.com/cnbc/50588010/

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Big crowds turn out for Stan Musial visitation

ST. LOUIS (AP) ? The entrance to the Cathedral Basilica looked more like that of a St. Louis Cardinals game on Thursday, just the way Stan Musial would have liked it.

Thousands of fans turned out for Musial's public visitation at the ornate Roman Catholic church, many of them bundled up against the bitter cold in red Cardinals jackets. Musial, a 24-time All-Star who remained a beloved figure in his adopted hometown a half-century after his playing career ended, died Saturday after years of declining health. He was 92.

Family, close friends and perhaps some of baseball's biggest names will be back at the cathedral for a funeral on Saturday. Thursday was for the fans.

Hours before the event began, hundreds lined Lindell Avenue leading to the steps of the cathedral. Just an hour into the six-hour visitation, 1,400 people had arrived, according to a woman keeping track.

When a bell chimed once as the doors opened, 68-year-old Evelyn Bourisaw, dressed in a red coat, exclaimed, "Time to play ball!"

Among the first to go in were Audrey Kissel, 86, and Erma Bergman, 88. The two were kindred spirits of Musial, not only of his generation but also former ballplayers. Kissel played second base and Bergman pitched in a women's professional league during World War II.

Rope lines moved mourners toward the open casket. Musial was dressed in a red blazer and a Cardinals necktie. His harmonica was in the front pocket.

Retired car salesman Bill Sanders, 64, was like many fans, as taken with Musial's good-natured ways as his considerable baseball prowess. Sanders noted that not once in a 22-year career did Musial get tossed out of a game.

"He was a true gentleman," Sanders said. "He even liked the umpires."

Certainly his baseball accomplishments were plentiful: a .331 lifetime average, seven NL batting titles, 475 homers and 3,630 career hits (1,815 at home and an equal number on the road). He helped the Cardinals to three World Series championships in the 1940s and another after his playing days ended ? he was general manager of the 1967 team that beat the Red Sox in seven games.

The GM job was short-lived, but Musial was a frequent figure at Busch Stadium, showing up for most opening days and many postseason games, sometimes playing the harmonica, always striking a pose of that unusual left-handed batting stance.

Source: http://news.yahoo.com/big-crowds-turn-stan-musial-visitation-215113341--mlb.html

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Parents, Don't Let Beyonc?, Let's Move! Spokeswoman, Tell Your ...

Beyonc??literally pushing soda to kids.

Sign the Petition Asking Beyonc??to Ditch Pepsi/Resign from Let?s Move!

In a sickening development involving the First Lady?s?Let?s Move!?initiative to improve the nutrition, fitness and health of the nation?s children, the initiative?s celebrity spokeswoman,?Beyonc?, accepted a?$50 million deal to sell Pepsi. She?ll be hawking soda to kids on TV, at grocery stores, on Pepsi cans, during the Super Bowl halftime and in other marketing formats for the foreseeable future.

What was she thinking? ?Back in 2011,?Beyonc? and the First Lady teamed up for Let?s Move?s! campaign against childhood obesity with this kid?s workout?video. But now,?Beyonc? is playing for the opposing team as well, promoting a drink that dozens of studies have identified as the main driver of America?s current childhood obesity epidemic.

Never mind that:

- ?For each additional 12 ounce soda children consumed each day, the odds of becoming obese increased by 60%.

- ?Pepsi, Coca-Cola and other soft drink manufacturers specifically target children, teens, African-American youth and Hispanic youth through their marketing.

- ?Soda consumption has also been linked to increased rates of?heart disease, diabetes and dental decay.

None of those depressing statistics seemed to phase?Beyonc?, mother to a one-year old daughter. ?And she certainly didn?t pause to question whether she would be sending a dangerous mixed message to America?s youth, when many view her as a dazzling role model.

But?Beyonc??s massive insensitivity and cognitive dissonance could actually be a watershed moment in the debate about food marketing to children ? if only America?s parents stand up and protest her ill-advised deal to market soda to their kids.??Celebrity endorsements are a fact of life in the food marketing world and a noisy grass roots uprising against?Beyonc? could get other celebrities to back off from endorsing soda, sugary drinks, chips, candy and other non-nutritious foods to impressionable kids. Remember, once upon a time, celebrities regularly hawked tobacco products. ?Now they wouldn?t be caught dead having any association with cigarettes.

If enough parents?signed this petition, both?Beyonc? and the White House would take notice. While?Beyonc? may not be able to extricate herself from her Pepsi contract, the least she could do is resign from Let?s Move! and donate her fee to childhood obesity prevention efforts. And the First Lady, who has done so much to promote healthy eating, physical activity and awareness about childhood obesity, needs to ensure that her partners/celebrity spokespersons walk the talk.

The White House knows that Beyonc??s Pepsi deal is an embarrassment to Let?s Move! and Michelle Obama, but has remained mum on the topic. Just last week, the?White House actually removed a?petition?from its ?We the People? website, posted by environmental activist Laurie David, asking that?Beyonc??be ousted from the inauguration lineup?because of her damaging deal with Pepsi. ?I can?t help but find it telling that the White House posted a detailed response to a ?We the People? petition asking the administration to construct a?Death Star,?but censored the?Beyonc? petition.

Well, the White House can?t censor this petition:

Sign the Petition Asking?Beyonc??to Ditch Pepsi/Resign from Let?s Move!

Please sign and share this petition link with your family, friends, neighbors and colleagues. ?If we don?t stand up to Big Soda and?Beyonc? pushing soda on our kids, no one will.

This post originally appeared on the Nancy Huehnergarth Consulting Blog.

?Follow Nancy Huehnergarth on Twitter: @nyshepa

Source: https://www.momsrising.org/blog/parents-dont-let-beyonce-lets-move-spokeswoman-tell-your-kids-to-guzzle-pepsi/

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Burger King drops supplier linked to horsemeat

LONDON (AP) ? British and Irish burger fans could face a Whopper shortage. Burger King has stopped buying beef from an Irish meat processor whose patties were found to contain traces of horsemeat.

The fast food chain said Thursday it had dropped Silvercrest Foods as a supplier for its U.K. and Ireland restaurants as a "voluntary and precautionary measure."

Last week Silvercrest, which is owned by ABP Food Group, shut down its production line and recalled 10 million burgers from supermarket shelves in Britain and Ireland after horse DNA was found in some beef products.

Burger King said the decision to drop the supplier "may mean that some of our products are temporarily unavailable." It stressed that "this is not a food safety issue."

The company added that there was "no evidence to suggest any of the Silvercrest product supplied to Burger King was affected" by the horsemeat contamination.

Rival McDonald's said it does not buy beef from Silvercrest or other affected suppliers.

The presence of horsemeat in beef is a sensitive issue in Britain and Ireland, which do not have a tradition of eating horses. The British tabloid The Sun reported the Burger King story under the headline "Shergar King," a reference to a famous racehorse.

Products from another Irish firm and one in Britain also were contaminated by horsemeat. Most had only small traces, but one burger of a brand sold by the British supermarket chain Tesco contained 29 percent horsemeat.

Irish food officials say an ingredient imported from an unspecified European country and used as filler in cheap burgers is the likely source of the horsemeat contamination.

Burger King says its patties are made from 100 percent beef.

Officials say the horsemeat poses no risk to human health, but the episode has raised food security worries.

More concern arose Thursday when lawmaker Mary Creagh, environment spokeswoman for Britain's opposition Labour Party, said that several horses slaughtered in the country last year had tested positive for phenylbutazone, an anti-inflammatory drug given to horses that can cause cancer in humans.

"It is possible that those animals entered the human food chain," she said.

The Food Standards Agency confirmed that meat from five horses had tested positive for the drug, but said none had been approved for sale in Britain. It said the relevant food safety authorities were informed in cases where the meat was exported to other countries.

The agency said no horsemeat in the current scandal contained phenylbutazone.

Very little horsemeat is sold in Britain but the country sends thousands of horses a year abroad to be killed for meat.

Source: http://news.yahoo.com/burger-king-drops-supplier-linked-horsemeat-125951290--finance.html

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Genome Donators Can Be Sleuthed Out

Using publicly available information, researchers found they could figure out the identities of 50 individuals who had loaned their genes to science. Karen Hopkin reports.

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Since the first human genome sequence was published, thousands of people have submitted their DNA for scientific analysis. They made these donations anonymously?or so they thought. Now, using publicly available information, researchers found they could figure out the identities of 50 individuals who had loaned their genes to science. Their results, although not the names of the people, are in the journal Science. [Melissa Gymrek et al, Identifying Personal Genomes by Surname Inference]

Biomedical research depends on the participation of human subjects, and issues of privacy have always been a concern. When scientists share genomic data, they first strip away identifying information, like the individual?s name and date of birth. But is that really enough?

Researchers looked at a specific set of markers in genomes whose sequences were in a public database. And they found that by matching up these markers with sequences that people had submitted to genealogy web sites, they could identify some of the genome donors? relatives and, with a bit more sleuthing, come up with their actual names.

Of course, many people now post online accounts of what?s on their minds or even on their menus. But even those who are relatively relaxed about their privacy might think twice about their genomes going public.

?Karen Hopkin

[The above text is a transcript of this podcast]
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Source: http://rss.sciam.com/click.phdo?i=21d768596e32ceac3c9226a91870772e

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